Kisspeptin Research

Full Citation Index

Kisspeptin Research: All Citations

Every Kisspeptin claim on this site cites one of the sources below. References are numbered to match inline citation markers used across all pages. DOIs and PubMed links provided where available.

  1. 1
    Seminara SB, et al. The GPR54 Gene as a Regulator of Puberty. New England Journal of Medicine. 2003;349:1614-1627. DOI: 10.1056/NEJMoa035322 https://www.nejm.org/doi/full/10.1056/NEJMoa035322 ↗
  2. 2
    Teles MG, et al. A GPR54-Activating Mutation in a Patient with Central Precocious Puberty. New England Journal of Medicine. 2008;358(7):709-715. DOI: 10.1056/NEJMoa073443 PMID: 18272894 https://pubmed.ncbi.nlm.nih.gov/18272894/ ↗
  3. 3
    Topaloglu AK, et al. Inactivating KISS1 Mutation and Hypogonadotropic Hypogonadism. New England Journal of Medicine. 2012;366(7):629-635. DOI: 10.1056/NEJMoa1111184 PMID: 22335740 https://pubmed.ncbi.nlm.nih.gov/22335740/ ↗
  4. 4
    Liu X, Lee K, Herbison AE. Kisspeptin excites gonadotropin-releasing hormone (GnRH) neurons through a phospholipase C/calcium-dependent pathway regulating multiple ion channels. Endocrinology. 2008. DOI: 10.1210/en.2008-0321 PMID: 18483150 https://pubmed.ncbi.nlm.nih.gov/18483150/ ↗
  5. 5
    George JT, et al. Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men. Journal of Clinical Endocrinology & Metabolism. 2011. DOI: 10.1210/jc.2011-0089 PMID: 21632807 https://pubmed.ncbi.nlm.nih.gov/21632807/ ↗
  6. 6
    George JT, et al. Exploring the pathophysiology of hypogonadism in men with type 2 diabetes: Kisspeptin-10 stimulates serum testosterone and LH secretion in men with type 2 diabetes and mild biochemical hypogonadism. Clinical Endocrinology. 2013;79(1):100-104. DOI: 10.1111/cen.12103 https://onlinelibrary.wiley.com/doi/10.1111/cen.12103 ↗
  7. 7
    Jayasena CN, Abbara A, Veldhuis JD, et al. Increasing LH Pulsatility in Women With Hypothalamic Amenorrhoea Using Intravenous Infusion of Kisspeptin-54. Journal of Clinical Endocrinology & Metabolism. 2014. DOI: 10.1210/jc.2013-1569 PMID: 24517142 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207927/ ↗
  8. 8
    Jayasena CN, et al. Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea, but chronic administration causes tachyphylaxis. Journal of Clinical Endocrinology & Metabolism. 2009;94(11):4315-4323. DOI: 10.1210/jc.2009-0406 PMID: 19820030 https://pubmed.ncbi.nlm.nih.gov/19820030/ ↗
  9. 9
    Abbara A, Jayasena CN, Christopoulos G, et al. Efficacy of Kisspeptin-54 to Trigger Oocyte Maturation in Women at High Risk of Ovarian Hyperstimulation Syndrome (OHSS) During In Vitro Fertilization (IVF) Therapy. Journal of Clinical Endocrinology & Metabolism. 2015;100(9):3322-3331. DOI: 10.1210/jc.2015-2332 PMID: 26192876 https://pubmed.ncbi.nlm.nih.gov/26192876/ ↗
  10. 10
    Jayasena CN, Abbara A, Comninos AN, et al. Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization. Journal of Clinical Investigation. 2014;124(8):3667-3677. DOI: 10.1172/JCI75730 PMID: 25036713 https://pubmed.ncbi.nlm.nih.gov/25036713/ ↗
  11. 11
    Abbara A, Clarke S, Islam R, et al. A second dose of kisspeptin-54 improves oocyte maturation in women at high risk of ovarian hyperstimulation syndrome: a Phase 2 randomized controlled trial. Human Reproduction. 2017;32(9):1915-1924. DOI: 10.1093/humrep/dex253 PMID: 28854728 https://pubmed.ncbi.nlm.nih.gov/28854728/ ↗
  12. 12
    d'Anglemont de Tassigny X, Jayasena C, Murphy KG, Dhillo WS, Colledge WH. Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo. PLoS One. 2017. DOI: 10.1371/journal.pone.0176821 PMID: 28464043 https://pmc.ncbi.nlm.nih.gov/articles/PMC5413024/ ↗
  13. 13
    Mills EG, et al. Effects of Kisspeptin on Sexual Brain Processing and Penile Tumescence in Men With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial. JAMA Network Open. 2023;6(2). DOI: 10.1001/jamanetworkopen.2022.54313 PMID: 36735255 https://pubmed.ncbi.nlm.nih.gov/36735255/ ↗
  14. 14
    Thurston L, Hunjan T, Ertl N, et al. Effects of Kisspeptin Administration in Women With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial. JAMA Network Open. 2022;5(10). DOI: 10.1001/jamanetworkopen.2022.36131 PMID: 36287566 https://pubmed.ncbi.nlm.nih.gov/36287566/ ↗
  15. 15
    Goodman RL, et al. Kisspeptin, Neurokinin B, and Dynorphin Act in the Arcuate Nucleus to Control Activity of the GnRH Pulse Generator in Ewes. Endocrinology. 2013;154(11):4259-4269. DOI: 10.1210/en.2013-1331 PMID: 23959940 https://pubmed.ncbi.nlm.nih.gov/23959940/ ↗
  16. 16
    Quennell JH, et al. Leptin Deficiency and Diet-Induced Obesity Reduce Hypothalamic Kisspeptin Expression in Mice. Endocrinology. 2011. DOI: 10.1210/en.2010-1100 PMID: 21325051 https://pmc.ncbi.nlm.nih.gov/articles/PMC3206710/ ↗
  17. 17
    Lee JH, et al. KiSS-1, a novel human malignant melanoma metastasis-suppressor gene. Journal of the National Cancer Institute. 1996;88(23):1731-1737. PMID: 8944003 https://pubmed.ncbi.nlm.nih.gov/8944003/ ↗
  18. 18
    Liu H, et al. Serum kisspeptin levels in polycystic ovary syndrome: A meta-analysis. Journal of Obstetrics and Gynaecology Research. 2021. DOI: 10.1111/jog.14767 PMID: 33765692 https://pubmed.ncbi.nlm.nih.gov/33765692/ ↗
  19. 19
    Dos Santos E, et al. KISS1/KISS1R in Cancer: Friend or Foe? Frontiers in Endocrinology. 2018. DOI: 10.3389/fendo.2018.00437 https://pmc.ncbi.nlm.nih.gov/articles/PMC6085450/ ↗
  20. 20
    Patel AH, Koysombat K, Pierret A, et al. Kisspeptin in functional hypothalamic amenorrhea: Pathophysiology and therapeutic potential. Annals of the New York Academy of Sciences. 2024. DOI: 10.1111/nyas.15220 PMID: 39287750 https://pubmed.ncbi.nlm.nih.gov/39287750/ ↗
  21. 21
    Kisspeptin Administration Stimulates Reproductive Hormones but Does Not Affect Anxiety in Humans. Journal of Clinical Endocrinology & Metabolism. 2025. DOI: 10.1210/clinem/dgaf128 PMID: 40036336 https://pubmed.ncbi.nlm.nih.gov/40036336/ ↗
  22. 22
    Velmurugan H, et al. Kisspeptin and its Current Clinical Status — A Systematic Review. Current Medicinal Chemistry. 2025;32(7):1313-1322. DOI: 10.2174/0109298673251224230919093656 PMID: 38265397 https://pubmed.ncbi.nlm.nih.gov/38265397/ ↗
  23. 23
    Izzi-Engbeaya C, Choudhury MM, Patel B, Dhillo WS. The effects of kisspeptin on food intake in women with overweight or obesity. Diabetes, Obesity and Metabolism. 2023. DOI: 10.1111/dom.15086 PMID: 37039248 https://pmc.ncbi.nlm.nih.gov/articles/PMC10946989/ ↗
  24. 24
    Intranasal kisspeptin administration rapidly stimulates gonadotropin release in humans. eBioMedicine. 2025. DOI: 10.1016/j.ebiom.2025.105689 PMID: 40215751 https://pmc.ncbi.nlm.nih.gov/articles/PMC12018048/ ↗