Kisspeptin Research

Kisspeptin Research: Full Citation Index

All Citations

Every Kisspeptin claim on this site cites one of the sources below. References are numbered to match inline citation markers used across all pages.

  1. Seminara SB, et al. The GPR54 Gene as a Regulator of Puberty. New England Journal of Medicine. 2003;349:1614-1627. ↗
  2. Teles MG, et al. A GPR54-Activating Mutation in a Patient with Central Precocious Puberty. New England Journal of Medicine. 2008;358(7):709-715. ↗
  3. Topaloglu AK, et al. Inactivating KISS1 Mutation and Hypogonadotropic Hypogonadism. New England Journal of Medicine. 2012;366(7):629-635. ↗
  4. Liu X, Lee K, Herbison AE. Kisspeptin excites gonadotropin-releasing hormone (GnRH) neurons through a phospholipase C/calcium-dependent pathway regulating multiple ion channels. Endocrinology. 2008. ↗
  5. George JT, et al. Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men. Journal of Clinical Endocrinology & Metabolism. 2011. ↗
  6. George JT, et al. Exploring the pathophysiology of hypogonadism in men with type 2 diabetes: Kisspeptin-10 stimulates serum testosterone and LH secretion in men with type 2 diabetes and mild biochemical hypogonadism. Clinical Endocrinology. 2013;79(1):100-104. ↗
  7. Jayasena CN, Abbara A, Veldhuis JD, et al. Increasing LH Pulsatility in Women With Hypothalamic Amenorrhoea Using Intravenous Infusion of Kisspeptin-54. Journal of Clinical Endocrinology & Metabolism. 2014. ↗
  8. Jayasena CN, et al. Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea, but chronic administration causes tachyphylaxis. Journal of Clinical Endocrinology & Metabolism. 2009;94(11):4315-4323. ↗
  9. Abbara A, Jayasena CN, Christopoulos G, et al. Efficacy of Kisspeptin-54 to Trigger Oocyte Maturation in Women at High Risk of Ovarian Hyperstimulation Syndrome (OHSS) During In Vitro Fertilization (IVF) Therapy. Journal of Clinical Endocrinology & Metabolism. 2015;100(9):3322-3331. ↗
  10. Jayasena CN, Abbara A, Comninos AN, et al. Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization. Journal of Clinical Investigation. 2014;124(8):3667-3677. ↗
  11. Abbara A, Clarke S, Islam R, et al. A second dose of kisspeptin-54 improves oocyte maturation in women at high risk of ovarian hyperstimulation syndrome: a Phase 2 randomized controlled trial. Human Reproduction. 2017;32(9):1915-1924. ↗
  12. d'Anglemont de Tassigny X, Jayasena C, Murphy KG, Dhillo WS, Colledge WH. Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo. PLoS One. 2017. ↗
  13. Mills EG, et al. Effects of Kisspeptin on Sexual Brain Processing and Penile Tumescence in Men With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial. JAMA Network Open. 2023;6(2). ↗
  14. Thurston L, Hunjan T, Ertl N, et al. Effects of Kisspeptin Administration in Women With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial. JAMA Network Open. 2022;5(10). ↗
  15. Goodman RL, et al. Kisspeptin, Neurokinin B, and Dynorphin Act in the Arcuate Nucleus to Control Activity of the GnRH Pulse Generator in Ewes. Endocrinology. 2013;154(11):4259-4269. ↗
  16. Quennell JH, et al. Leptin Deficiency and Diet-Induced Obesity Reduce Hypothalamic Kisspeptin Expression in Mice. Endocrinology. 2011. ↗
  17. Lee JH, et al. KiSS-1, a novel human malignant melanoma metastasis-suppressor gene. Journal of the National Cancer Institute. 1996;88(23):1731-1737. ↗
  18. Liu H, et al. Serum kisspeptin levels in polycystic ovary syndrome: A meta-analysis. Journal of Obstetrics and Gynaecology Research. 2021. ↗
  19. Dos Santos E, et al. KISS1/KISS1R in Cancer: Friend or Foe? Frontiers in Endocrinology. 2018. ↗
  20. Patel AH, Koysombat K, Pierret A, et al. Kisspeptin in functional hypothalamic amenorrhea: Pathophysiology and therapeutic potential. Annals of the New York Academy of Sciences. 2024. ↗
  21. Kisspeptin Administration Stimulates Reproductive Hormones but Does Not Affect Anxiety in Humans. Journal of Clinical Endocrinology & Metabolism. 2025. ↗
  22. Velmurugan H, et al. Kisspeptin and its Current Clinical Status — A Systematic Review. Current Medicinal Chemistry. 2025;32(7):1313-1322. ↗
  23. Izzi-Engbeaya C, Choudhury MM, Patel B, Dhillo WS. The effects of kisspeptin on food intake in women with overweight or obesity. Diabetes, Obesity and Metabolism. 2023. ↗
  24. Intranasal kisspeptin administration rapidly stimulates gonadotropin release in humans. eBioMedicine. 2025. ↗