# Kisspeptin Research: Full Citation Index

> Complete reference index for the Kisspeptin research record — PubMed URLs, DOIs, and full citations for every peer-reviewed study summarized on this site.

## All Citations

Every Kisspeptin claim on this site cites one of the sources below.

[1] Seminara SB, et al. The GPR54 Gene as a Regulator of Puberty. New England Journal of Medicine. 2003;349:1614-1627. DOI: 10.1056/NEJMoa035322. https://www.nejm.org/doi/full/10.1056/NEJMoa035322

[2] Teles MG, et al. A GPR54-Activating Mutation in a Patient with Central Precocious Puberty. New England Journal of Medicine. 2008;358(7):709-715. DOI: 10.1056/NEJMoa073443. PMID: 18272894. https://pubmed.ncbi.nlm.nih.gov/18272894/

[3] Topaloglu AK, et al. Inactivating KISS1 Mutation and Hypogonadotropic Hypogonadism. New England Journal of Medicine. 2012;366(7):629-635. DOI: 10.1056/NEJMoa1111184. PMID: 22335740. https://pubmed.ncbi.nlm.nih.gov/22335740/

[4] Liu X, Lee K, Herbison AE. Kisspeptin excites gonadotropin-releasing hormone (GnRH) neurons through a phospholipase C/calcium-dependent pathway regulating multiple ion channels. Endocrinology. 2008. DOI: 10.1210/en.2008-0321. PMID: 18483150. https://pubmed.ncbi.nlm.nih.gov/18483150/

[5] George JT, et al. Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men. Journal of Clinical Endocrinology & Metabolism. 2011. DOI: 10.1210/jc.2011-0089. PMID: 21632807. https://pubmed.ncbi.nlm.nih.gov/21632807/

[6] George JT, et al. Exploring the pathophysiology of hypogonadism in men with type 2 diabetes: Kisspeptin-10 stimulates serum testosterone and LH secretion. Clinical Endocrinology. 2013;79(1):100-104. DOI: 10.1111/cen.12103. https://onlinelibrary.wiley.com/doi/10.1111/cen.12103

[7] Jayasena CN, Abbara A, Veldhuis JD, et al. Increasing LH Pulsatility in Women With Hypothalamic Amenorrhoea Using Intravenous Infusion of Kisspeptin-54. Journal of Clinical Endocrinology & Metabolism. 2014. DOI: 10.1210/jc.2013-1569. PMID: 24517142. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207927/

[8] Jayasena CN, et al. Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea, but chronic administration causes tachyphylaxis. Journal of Clinical Endocrinology & Metabolism. 2009;94(11):4315-4323. DOI: 10.1210/jc.2009-0406. PMID: 19820030. https://pubmed.ncbi.nlm.nih.gov/19820030/

[9] Abbara A, Jayasena CN, Christopoulos G, et al. Efficacy of Kisspeptin-54 to Trigger Oocyte Maturation in Women at High Risk of OHSS During IVF Therapy. Journal of Clinical Endocrinology & Metabolism. 2015;100(9):3322-3331. DOI: 10.1210/jc.2015-2332. PMID: 26192876. https://pubmed.ncbi.nlm.nih.gov/26192876/

[10] Jayasena CN, Abbara A, Comninos AN, et al. Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization. Journal of Clinical Investigation. 2014;124(8):3667-3677. DOI: 10.1172/JCI75730. PMID: 25036713. https://pubmed.ncbi.nlm.nih.gov/25036713/

[11] Abbara A, Clarke S, Islam R, et al. A second dose of kisspeptin-54 improves oocyte maturation in women at high risk of OHSS: a Phase 2 RCT. Human Reproduction. 2017;32(9):1915-1924. DOI: 10.1093/humrep/dex253. PMID: 28854728. https://pubmed.ncbi.nlm.nih.gov/28854728/

[12] d'Anglemont de Tassigny X, Jayasena C, Murphy KG, Dhillo WS, Colledge WH. Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo. PLoS One. 2017. DOI: 10.1371/journal.pone.0176821. PMID: 28464043. https://pmc.ncbi.nlm.nih.gov/articles/PMC5413024/

[13] Mills EG, et al. Effects of Kisspeptin on Sexual Brain Processing and Penile Tumescence in Men With Hypoactive Sexual Desire Disorder. JAMA Network Open. 2023;6(2). DOI: 10.1001/jamanetworkopen.2022.54313. PMID: 36735255. https://pubmed.ncbi.nlm.nih.gov/36735255/

[14] Thurston L, Hunjan T, Ertl N, et al. Effects of Kisspeptin Administration in Women With Hypoactive Sexual Desire Disorder. JAMA Network Open. 2022;5(10). DOI: 10.1001/jamanetworkopen.2022.36131. PMID: 36287566. https://pubmed.ncbi.nlm.nih.gov/36287566/

[15] Goodman RL, et al. Kisspeptin, Neurokinin B, and Dynorphin Act in the Arcuate Nucleus to Control Activity of the GnRH Pulse Generator in Ewes. Endocrinology. 2013;154(11):4259-4269. DOI: 10.1210/en.2013-1331. PMID: 23959940. https://pubmed.ncbi.nlm.nih.gov/23959940/

[16] Quennell JH, et al. Leptin Deficiency and Diet-Induced Obesity Reduce Hypothalamic Kisspeptin Expression in Mice. Endocrinology. 2011. DOI: 10.1210/en.2010-1100. PMID: 21325051. https://pmc.ncbi.nlm.nih.gov/articles/PMC3206710/

[17] Lee JH, et al. KiSS-1, a novel human malignant melanoma metastasis-suppressor gene. Journal of the National Cancer Institute. 1996;88(23):1731-1737. PMID: 8944003. https://pubmed.ncbi.nlm.nih.gov/8944003/

[18] Liu H, et al. Serum kisspeptin levels in polycystic ovary syndrome: A meta-analysis. Journal of Obstetrics and Gynaecology Research. 2021. DOI: 10.1111/jog.14767. PMID: 33765692. https://pubmed.ncbi.nlm.nih.gov/33765692/

[19] Dos Santos E, et al. KISS1/KISS1R in Cancer: Friend or Foe? Frontiers in Endocrinology. 2018. DOI: 10.3389/fendo.2018.00437. https://pmc.ncbi.nlm.nih.gov/articles/PMC6085450/

[20] Patel AH, Koysombat K, Pierret A, et al. Kisspeptin in functional hypothalamic amenorrhea: Pathophysiology and therapeutic potential. Annals of the New York Academy of Sciences. 2024. DOI: 10.1111/nyas.15220. PMID: 39287750. https://pubmed.ncbi.nlm.nih.gov/39287750/

[21] Kisspeptin Administration Stimulates Reproductive Hormones but Does Not Affect Anxiety in Humans. Journal of Clinical Endocrinology & Metabolism. 2025. DOI: 10.1210/clinem/dgaf128. PMID: 40036336. https://pubmed.ncbi.nlm.nih.gov/40036336/

[22] Velmurugan H, et al. Kisspeptin and its Current Clinical Status — A Systematic Review. Current Medicinal Chemistry. 2025;32(7):1313-1322. DOI: 10.2174/0109298673251224230919093656. PMID: 38265397. https://pubmed.ncbi.nlm.nih.gov/38265397/

[23] Izzi-Engbeaya C, Choudhury MM, Patel B, Dhillo WS. The effects of kisspeptin on food intake in women with overweight or obesity. Diabetes, Obesity and Metabolism. 2023. DOI: 10.1111/dom.15086. PMID: 37039248. https://pmc.ncbi.nlm.nih.gov/articles/PMC10946989/

[24] Intranasal kisspeptin administration rapidly stimulates gonadotropin release in humans. eBioMedicine. 2025. DOI: 10.1016/j.ebiom.2025.105689. PMID: 40215751. https://pmc.ncbi.nlm.nih.gov/articles/PMC12018048/

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The KISS1 record — mechanism, isoforms, and clinical trials — indexed here. Not a clinic, not a vendor.